Clinical Trials and Studies
Clinical trials help discover ways to prevent or manage various health conditions. Research must show procedures or medicines are safe and effective before they can be approved for use.
Pregnancy and Sleep Quality Study
Texas A&M University College of Dentistry researchers are conducting a pilot study on the effectiveness of an oral appliance to improve sleep quality, breathing & snoring. Snoring can be a serious problem that can affect your health and that of your developing child. It is associated with poor quality sleep, high blood pressure, heart disease, preeclampsia and preterm delivery.
Eligibility: If you are pregnant, at least 18 years old, and snore, and have adequate dental health to wear an oral appliance, you may qualify.
Requirements: The study is 5-weeks long and requires regular visits to the Texas A&M University College of Dentistry, 3302 Gaston Avenue, Dallas, TX. The study involves doing home sleep tests for at least 6 nights, & wearing an oral appliance at night for 4 weeks.
Benefits, Risks & Compensation: Potential benefits include reduction of snoring; improved breathing and sleep quality.
Potential risks & discomforts are minimal.
Compensation of $150 will be provided and you will be able to keep the custom-fitted oral appliance at the completion of the study. There is no cost to you to participate.
Study Title: Oral Appliance Therapy for Improving Sleep Quality during Pregnancy: A Controlled Clinical Trial
Principal Investigators: Dr. Emet Schneiderman, eschneiderman@tamu.edu, Dr. Preetam Schramm, schramm@tamu.edu
Funded by: The Baylor Oral Health Foundation and Airway Management Inc.
For more information, contact: Ms. Zohre German (Study Coordinator) (214) 828-8291 or german@tamu.edu
IRB Number: 2018-0048-CD-EXP IRB Approval Date: 05/24/2018
Do you Snore, Mouth Breathe and have Periodontitis?
Snoring, mouth breathing, and periodontitis can be serious problems that affect your overall health. They are associated with poor quality sleep, high blood pressure, heart disease and dementia. Texas A&M University College of Dentistry researchers are conducting a study on an oral appliance that may improve periodontitis in addition to sleep quality. Periodontitis is inflammation of gums and tissues that support the teeth; if untreated, can lead to bone loss and the loosening of teeth as well as tooth loss.
Atrial Fibrillation and Sleep Study
You may be eligible to participate in a research study using oral appliance therapy to treat snoring, improve sleep and breathing. Texas A&M University College of Dentistry researchers are conducting a pilot study on the effectiveness of an oral appliance to improve sleep quality, breathing & snoring. Snoring can be a serious problem that can affect your health. Atrial fibrillation increases the risk of death in patients with sleep-disordered breathing compared with patients without any sleep-disordered breathing.
Completed Studies
Schramm P, Hui J, Moura P, German Z, Lin JY, Stenberg W, and Schneiderman E. “Polypharmacy Impacts Home Sleep Test Results in OSA Patients Receiving Oral Appliance Therapy.” Dental Sleep Practice, Autumn 2024, 44–46. https://dentalsleeppractice.com/polypharmacy-impacts-home-sleep-test-results-in-osa-patients-receiving-oral-appliance-therapy/
Schramm P, Das N, Schneiderman E, German Z, Hui J, Wilson D, Spence JS, Moura P, Chapman SB. Snoring Remediation with Oral Appliance Therapy Potentially Reverses Cognitive Impairment: An Intervention Controlled Pilot Study. Geriatrics. 2021; 6(4):107. https://doi.org/10.3390/geriatrics6040107
Schneiderman E, Schramm P, Hui J, Wilson PD, Moura P, German Z, McCann A, Newton M. Randomized Trial of 2 Self-Titrated Oral Appliances for Airway Management. Journal of Dental Research. 2020 Sep:22034520956977. DOI: 10.1177/0022034520956977.
https://journals.sagepub.com/doi/10.1177/0022034520956977
Newton M, Schneiderman E, Hui J, Wilson D, Moura P, German Z, Schramm P. Prescribed Medications Confound Oral Appliance Therapy in Obstructive Sleep Apnea. Journal of Dental Research, Special Issue, Abstract #3599, 2020. https://iadr.abstractarchives.com/abstract/20iags-3322317/prescribed-medications-confound-oral-appliance-therapy-in-obstructive-sleep-apnea
Newton M, Schneiderman E, Hui J, Wilson PD, Moura P, German Z, McCann A, Bender B, Schramm P. Oral Appliances Efficacious in Treating Severe Obstructive Sleep Apnea Patients. Journal of Dental Research 97, Special Issue A, Abstract # 2089, 2019. https://iadr.abstractarchives.com/abstract/19iags-3186937/oral-appliances-efficacious-in-treating-severe-obstructive-sleep-apnea-patients